The Minnesota Twins (Major League Baseball) and the Vikings (NFL football) both call the Hubert H. Humphrey Metrodome home. The stadium is at the east end of downtown Minneapolis. Several blocks farther west in the city's Warehouse District, the Target Center is home to the Minnesota Timberwolves (NBA) and Lynx (WNBA) basketball teams. The Hennepin County board on May 3, 2005 approved a new ballpark for the Twins in the Warehouse District, across the street from the Target Center.

Women's football is played by the Minnesota Vixens, though that team does not appear to have a home venue.